Peptide specific monoclonal antibodies of Leptospiral LigA for acute diagnosis of leptospirosis

@inproceedings{Kanagavel2017PeptideSM,
  title={Peptide specific monoclonal antibodies of Leptospiral LigA for acute diagnosis of leptospirosis},
  author={Murugesan Kanagavel and Santhanam Shanmughapriya and Kayanam Vijaya Lalitha Aishwarya and Karuppiah Ponmurugan and Kasi Murugan and Naif Abdullah Al-Dhabi and K. Natarajaseenivasan},
  booktitle={Scientific Reports},
  year={2017}
}
Leptospirosis is underdiagnosed due to low sensitivity, need of specialised equipment, and expensive reagents for serological and molecular diagnosis respectively. Considering the sensitivity, rapidity, inexpensive reagents and collection of clinical samples, the monoclonal antibody based antigen detection method from urine samples has been developed and evaluated. LigA (LK90) based B-cell specific epitopes were predicted and synthesised as peptides for the production of monoclonal antibody… CONTINUE READING

Citations

Publications citing this paper.

References

Publications referenced by this paper.
Showing 1-10 of 31 references

Multilocus sequence typing (MLST) of leptospiral strains isolated from two geographic locations of Tamil Nadu, India.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases • 2016
View 1 Excerpt

A new loop-mediated isothermal amplification method for rapid, simple, and sensitive detection of Leptospira spp. in urine

N Koizumi
J. Clin. Microbiol • 2012