Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity.

@article{Reiter1997PeptidespecificKO,
  title={Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity.},
  author={Yoram Reiter and Angelina di Carlo and Lars Fugger and Jan Engberg and Ira Pastan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 9},
  pages={4631-6}
}
Specificity in the immune system is dictated and regulated by specific recognition of peptide/major histocompatibility complex (MHC) complexes by the T cell receptor. Such peptide/MHC complexes are a desirable target for novel approaches in immunotherapy because of their highly restricted fine specificity. Recently, phage display was used to isolate an antibody that has T cell receptor-like specificity. It recognizes mouse MHC class I H-2Kk molecules complexed with a H-2Kk-restricted influenza… CONTINUE READING

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