Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.

@article{Spagnoli1995PeptidespecificCI,
  title={Peptide-specific CTL in tumor infiltrating lymphocytes from metastatic melanomas expressing MART-1/Melan-A, gp100 and Tyrosinase genes: a study in an unselected group of HLA-A2.1-positive patients.},
  author={Giulio Cesare Spagnoli and Christoph G. W. Sch{\"a}fer and Thomas Willimann and Thomas Z Kocher and Antonio Amoroso and A. Alebi{\'c} Jureti{\'c} and Markus Zuber and U Luscher and Felix Harder and Michael M. G. Heberer},
  journal={International journal of cancer},
  year={1995},
  volume={64 5},
  pages={
          309-15
        }
}
Peptide specificity of cultured tumor-infiltrating lymphocytes (TIL) was systematically investigated in a group of HLA-A2.1+ metastatic melanoma patients consecutively referred to our department for surgical treatment. Seven samples from 6 patients were studied. All surgical specimens showed evidence of gp 100, MART-1/Melan-A and Tyrosinase gene expression as detectable by reverse PCR (rPCR). Cultured TIL from 2 patients displayed cytotoxic activity against autologous or HLA-matched EBV… CONTINUE READING
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