Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells.

@article{Peruzzi1996PeptideSR,
  title={Peptide sequence requirements for the recognition of HLA-B*2705 by specific natural killer cells.},
  author={M. Peruzzi and Kenneth C. Parker and Eric O Long and Mauro Severo Malnati},
  journal={Journal of immunology},
  year={1996},
  volume={157 8},
  pages={3350-6}
}
NK clones that were inhibited by target cell expression of HLA-B*2705 displayed peptide-specific recognition of HLA-B*2705. To evaluate the specificity of this recognition, synthetic versions of 14 endogenous ligands of HLA-B*2705 were tested for their ability to provide protection from NK-mediated lysis by binding to surface HLA-B*2705 molecules on RMA-S cells deficient in the transporter for Ag presentation. Several unrelated peptides inhibited lysis by the same NK clones. Despite similar… CONTINUE READING

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