Peptide scanning for studying structure-activity relationships in drug discovery.

@article{Jamieson2013PeptideSF,
  title={Peptide scanning for studying structure-activity relationships in drug discovery.},
  author={Andrew George Jamieson and Nicolas Boutard and David Sabatino and William D Lubell},
  journal={Chemical biology & drug design},
  year={2013},
  volume={81 1},
  pages={148-65}
}
Peptide-based therapeutics have grown in importance over the last few decades. Furthermore, peptides have been extensively used as lead compounds in the drug discovery process to investigate the nature of chemical space required for molecular recognition and activity at a variety of targets. This critical commentary reviews scanning techniques, which employ natural and non-proteinogenic amino acids to facilitate understanding of structural requirements for peptide biological activity. The value… CONTINUE READING
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