Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate.

Abstract

Peptide release on the ribosome is catalyzed by protein release factors (RFs) on recognition of stop codons positioned in the A site of the small ribosomal subunit. Here we show that the 2' OH of the peptidyl-tRNA substrate plays an essential role in catalysis of the peptide release reaction. These observations parallel earlier studies of the mechanism of… (More)
DOI: 10.1261/rna.1057908

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Cite this paper

@article{Brunelle2008PeptideRO, title={Peptide release on the ribosome depends critically on the 2' OH of the peptidyl-tRNA substrate.}, author={Julie L. Brunelle and Jeffrey Jon Shaw and Elaine M. Youngman and Rachel Green}, journal={RNA}, year={2008}, volume={14 8}, pages={1526-31} }