Peptide pheromone-dependent regulation of antimicrobial peptide production in Gram-positive bacteria: a case of multicellular behavior

@article{Kleerebezem2001PeptidePR,
  title={Peptide pheromone-dependent regulation of antimicrobial peptide production in Gram-positive bacteria: a case of multicellular behavior},
  author={Michiel Kleerebezem and Luis E N Quadri},
  journal={Peptides},
  year={2001},
  volume={22},
  pages={1579-1596}
}
Quorum sensing enables unicellular organisms to behave in a multicellular way by allowing population-wide synchronized adaptive responses that involve modulation of a wide range of physiological responses in a cell density-, cell proximity- or growth phase-dependent manner. Examples of processes modulated by quorum sensing are the development of genetic competence, conjugative plasmid transfer, sporulation and cell differentiation, biofilm formation, virulence response, production of… 
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An overview of the characteristics of autoinducing peptide-based quorum sensing systems, their application in various gram-positive bacteria, and the discovery of new systems in natural and engineered ecosystems is provided.
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  • 2004
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The high specificity of the initial signal sensing and the importance for expressing special virulence traits make this type of gene expression control a promising target for the development of novel therapeutics.
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It is important that food microbiologists have an awareness and an understanding of the mechanisms involved in bacterial quorum sensing, since strategies targetingQuorum sensing may offer a means to control the growth of undesirable bacteria in foods.
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The results of analyses support a model in which the CbnK-CbnR two-component signal transduction system is necessary and sufficient to transduce the signal of the peptide autoinducer CS into the activation of the promoters that drive the expression of the genes required for production of the carnobacterial peptide antibiotics and the immunity proteins that protect the producer bacterium.
Quorum sensing: a primer for food microbiologists.
TLDR
It is important that food microbiologists have an awareness and an understanding of the mechanisms involved in bacterial quorum sensing, since strategies targetingQuorum sensing may offer a means to control the growth of undesirable bacteria in foods.
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TLDR
The results demonstrate the potential of genomics and molecular tools for elucidating the functions of uncharacterized QS genes and identifying new AIPs in the L. plantarum genome, as well as their implications on future QS research in lactobacilli.
The RNPP family of quorum-sensing proteins in Gram-positive bacteria
TLDR
In this work, insights of the mechanism of protein-signaling peptide binding as well as the molecular interaction among receptor protein, signaling peptide, and target DNA have changed some earlier perceptions of quorum sensing.
Cell-cell communication in food related bacteria.
TLDR
The identified quorum-sensing mechanisms in several food related Gram-negative and Gram-positive bacteria, including bacteriocin synthesis, luxS quorum sensing and interactions between sourdough starter lactic acid bacteria are reviewed.
Regulation of antimicrobial peptide production by autoinducer-mediated quorum sensing in lactic acid bacteria
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  • Medicine
    Antonie van Leeuwenhoek
  • 2004
TLDR
Cell–cell communication has emerged as the key regulatory mechanism that controls the production of many of these antimicrobial peptides via a regulatory strategy denominated quorum sensing, which allows population-wide synchronised production of antimacterial peptides as a function of cell density.
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