Peptide phage display as a tool for drug discovery: targeting membrane receptors.

@article{Molek2011PeptidePD,
  title={Peptide phage display as a tool for drug discovery: targeting membrane receptors.},
  author={Peter Molek and B. Strukelj and Toma{\vz} Bratkovi{\vc}},
  journal={Molecules},
  year={2011},
  volume={16 1},
  pages={857-87}
}
Ligands selected from phage-displayed random peptide libraries tend to be directed to biologically relevant sites on the surface of the target protein. Consequently, peptides derived from library screenings often modulate the target protein's activity in vitro and in vivo and can be used as lead compounds in drug design and as alternatives to antibodies for target validation in both genomics and drug discovery. This review discusses the use of phage display to identify membrane receptor… CONTINUE READING

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