Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80

@article{Lu2009PeptideNA,
  title={Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80},
  author={B. Lu and Yanhua Su and Sudipto Das and Haikun Wang and Y. Wang and Jin Liu and Dejian Ren},
  journal={Nature},
  year={2009},
  volume={457},
  pages={741-744}
}
Several neurotransmitters act through G-protein-coupled receptors to evoke a ‘slow’ excitation of neurons. These include peptides, such as substance P and neurotensin, as well as acetylcholine and noradrenaline. Unlike the fast (approximately millisecond) ionotropic actions of small-molecule neurotransmitters, the slow excitation is not well understood at the molecular level, but can be mainly attributed to suppressing K+ currents and/or activating a non-selective cation channel. The molecular… Expand
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