Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: a potential theranostic agent

@inproceedings{Accardo2012PeptidemodifiedLF,
  title={Peptide-modified liposomes for selective targeting of bombesin receptors overexpressed by cancer cells: a potential theranostic agent},
  author={Antonella Accardo and Giuseppina Salsano and Anna Morisco and M. Trabucco Aurilio and Antonio Parisi and Francesco Maione and Carla Cicala and Diego Tesauro and Luigi Aloj and Giuseppe De Rosa and Giancarlo Morelli},
  booktitle={International journal of nanomedicine},
  year={2012}
}
OBJECTIVES Drug delivery systems consisting of liposomes displaying a cell surface receptor-targeting peptide are being developed to specifically deliver chemotherapeutic drugs to tumors overexpressing a target receptor. This study addresses novel liposome composition approaches to specifically target tissues overexpressing bombesin (BN) receptors. METHODS A new amphiphilic peptide derivative (MonY-BN) containing the BN(7-14) peptide, the DTPA (diethylenetriaminepentaacetate) chelating agent… CONTINUE READING

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