Peptide mimotopes of rabies virus glycoprotein with immunogenic activity.

@article{Houimel2009PeptideMO,
  title={Peptide mimotopes of rabies virus glycoprotein with immunogenic activity.},
  author={Mehdi Houimel and Koussay Dellagi},
  journal={Vaccine},
  year={2009},
  volume={27 34},
  pages={4648-55}
}
A random constrained hexapeptide phage display library (Cys-6aa-Cys) was screened with purified neutralizing human anti-rabies virus IgG antibodies (hRABVIgG) to identify peptides that correspond to or mimic natural epitopes on rabies virus glycoprotein (RABVG) and to investigate their immunogenicities in vivo. After four rounds of biopanning, 20 phage clones randomly selected for their specificity to hRABVIgG, effectively blocked the binding of the inactive rabies virus (RABV) to hRABVIgG. The… CONTINUE READING

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