Peptide mimotopes of malondialdehyde epitopes for clinical applications in cardiovascular disease[S]

@inproceedings{Amir2012PeptideMO,
  title={Peptide mimotopes of malondialdehyde epitopes for clinical applications
in cardiovascular disease[S]},
  author={Shahzada Amir and Karsten Hartvigsen and Ayelet Gonen and Gregor Leibundgut and Xuchu Que and Erika Jensen-Jarolim and Oswald F. Wagner and Sotirios Tsimikas and Joseph L. Witztum and Christoph J. Binder},
  booktitle={Journal of lipid research},
  year={2012}
}
Autoantibodies specific for malondialdehyde-modified LDL (MDA-LDL) represent potential biomarkers to predict cardiovascular risk. However, MDA-LDL is a high variability antigen with limited reproducibility. To identify peptide mimotopes of MDA-LDL, phage display libraries were screened with the MDA-LDL-specific IgM monoclonal Ab LRO4, and the specificity and antigenic properties of MDA mimotopes were assessed in vitro and in vivo. We identified one 12-mer linear (P1) and one 7-mer cyclic (P2… CONTINUE READING

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We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
We detected IgG and IgM autoAbs to both MDA mimotopes in sera of healthy subjects and patients with myocardial infarction and stable angina pectoris undergoing percutaneous coronary intervention , and the titers of autoAbs correlated significantly with respective Ab titers against MDA - LDL .
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