Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens.

@article{Wizemann1996PeptideMS,
  title={Peptide methionine sulfoxide reductase contributes to the maintenance of adhesins in three major pathogens.},
  author={T. M. Wizemann and Jackob Moskovitz and Barbara J Pearce and Diana R. Cundell and Cindy Grove Arvidson and Magdalene So and Herbert Weissbach and Nathan Brot and H R Masure},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 15},
  pages={7985-90}
}
Pathogenic bacteria rely on adhesins to bind to host tissues. Therefore, the maintenance of the functional properties of these extracellular macromolecules is essential for the pathogenicity of these microorganisms. We report that peptide methionine sulfoxide reductase (MsrA), a repair enzyme, contributes to the maintenance of adhesins in Streptococcus pneumoniae, Neisseria gonorrhoeae, and Escherichia coli. A screen of a library of pneumococcal mutants for loss of adherence uncovered a MsrA… CONTINUE READING

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