Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis.

@article{Luo2014PeptideMC,
  title={Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis.},
  author={Hong Luo and S Hong and Rosa Sgambelluri and Evan Angelos and Xuan Li and Jonathan D. Walton},
  journal={Chemistry & biology},
  year={2014},
  volume={21 12},
  pages={1610-7}
}
Amatoxins are ribosomally encoded and posttranslationally modified peptides that account for the majority of fatal mushroom poisonings of humans. A representative amatoxin is the bicyclic octapeptide α-amanitin, formed via head-to-tail macrocyclization, which is ribosomally biosynthesized as a 35-amino acid propeptide in Amanita bisporigera and in the distantly related mushroom Galerina marginata. Although members of the prolyl oligopeptidase (POP) family of serine proteases have been proposed… CONTINUE READING

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Peptide Macrocyclization Catalyzed by a Prolyl Oligopeptidase Involved in a-Amanitin Biosynthesis

  • Luo
  • Chemistry & Biology
  • 2014

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