Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin.

@article{Ouellette1999PeptideLA,
  title={Peptide localization and gene structure of cryptdin 4, a differentially expressed mouse paneth cell alpha-defensin.},
  author={Andr{\'e} Joseph Ouellette and Dalila Darmoul and Dai Ngia Tran and Kenneth M. Huttner and Jun Ting Yuan and Michael E Selsted},
  journal={Infection and immunity},
  year={1999},
  volume={67 12},
  pages={
          6643-51
        }
}
Paneth cells in crypts of the small intestine express antimicrobial peptides, including alpha-defensins, termed cryptdins in mice. Of the known Paneth cell alpha-defensins, the cryptdin 4 gene is unique, because it is inactive in the duodenum and expressed at maximal levels in the distal small bowel (D. Darmoul and A. J. Ouellette, Am. J. Physiol. 271:G68-G74, 1996). With a cryptdin 4-specific antibody, immunohistochemical staining of ileal Paneth cells was strong and specific for cytoplasmic… CONTINUE READING

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