Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells.

@article{Nitin2004PeptidelinkedMB,
  title={Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells.},
  author={Nitin Nitin and Philip J Santangelo and Gloria Y. K. Kim and Shuming Nie and Gang Bao},
  journal={Nucleic acids research},
  year={2004},
  volume={32 6},
  pages={e58}
}
Real-time visualization of specific endogenous mRNA expression in vivo has the potential to revolutionize medical diagnosis, drug discovery, developmental and molecular biology. However, conventional liposome- or dendrimer-based cellular delivery of molecular probes is inefficient, slow, and often detrimental to the probes. Here we demonstrate the rapid and sensitive detection of RNA in living cells using peptide-linked molecular beacons that possess self-delivery, targeting and reporting… CONTINUE READING

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