Peptide ligands that bind IgM antibodies and block interaction with antigen.

@article{Glee1999PeptideLT,
  title={Peptide ligands that bind IgM antibodies and block interaction with antigen.},
  author={Pati M. Glee and Seth H. Pincus and Deirdre K. McNamer and Michael J. Smith and James B. Burritt and Jim E. Cutler},
  journal={Journal of immunology},
  year={1999},
  volume={163 2},
  pages={826-33}
}
We have selected a peptide-display phage library on IgM Abs and identified a panel of phage-expressing peptides that bind to IgM Abs in general, but not to Abs of other classes. A synthetic peptide corresponding to one of the displayed peptide sequences also binds to IgM Abs. The peptides bind to both soluble pentameric Abs and to monomeric cell-surface IgM. The phage-displayed and synthetic peptides inhibit the binding of IgM Abs to Ag. These peptides may create confounding artifacts when IgM… CONTINUE READING