Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening.

@article{Dutta2013PeptideLF,
  title={Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening.},
  author={Sanjib Dutta and T. Scott Chen and Amy E. Keating},
  journal={ACS chemical biology},
  year={2013},
  volume={8 4},
  pages={778-88}
}
Pro-survival members of the Bcl-2 protein family inhibit cell death by binding short helical BH3 motifs in pro-apoptotic proteins. Mammalian pro-survival proteins Bcl-x(L), Bcl-2, Bcl-w, Mcl-1, and Bfl-1 bind with varying affinities and specificities to native BH3 motifs, engineered peptides, and small molecules. Biophysical studies have determined interaction patterns for these proteins, particularly for the most-studied family members Bcl-x(L) and Mcl-1. Bfl-1 is a pro-survival protein… CONTINUE READING
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