Peptide ligand targeted delivery to EGFR Expressing Cancer Cells in Vitro and in Vivo

Epidermal growth factor receptor (EGFR) is an important cell surface protein that's over-expressed in many human cancer cells. We designed a novel peptide ligand (named D4) based on the crystal structure of EGFR that can bind to a surface pocket on EGFR. D4-PEG-lipid conjugates were made and used to modify liposome surface. Confocal fluorescence microscopy… (More)