Peptide inhibitors of hepatitis C virus core oligomerization and virus production.

@article{Kota2009PeptideIO,
  title={Peptide inhibitors of hepatitis C virus core oligomerization and virus production.},
  author={Smitha Kota and Carlos Coito and Guillaume Mousseau and J-P Lavergne and Arthur Donny Strosberg},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 6},
  pages={
          1319-28
        }
}
Hepatitis C virus (HCV) nucleocapsid assembly requires dimerization of the core protein, an essential step in the formation of the virus particle. We developed a novel quantitative assay for monitoring this protein-protein interaction, with the goal of identifying inhibitors of core dimerization that might block HCV production in infected Huh-7.5 hepatoma cells. Two core-derived, 18-residue peptides were found that inhibited the dimerization of a fragment of core comprising residues 1-106… CONTINUE READING

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