Peptide identification using vectors of small fragment ions.

  title={Peptide identification using vectors of small fragment ions.},
  author={Davide Cittaro and Dario Borsotti and Alessio Maiolica and Elisabetta Argenzio and Juri Rappsilber},
  journal={Journal of proteome research},
  volume={4 3},
Traditionally, peptide identification using fragmentation spectra relies on extracting the maximum amount of information from spectra. Using different combinations of small ion masses, we show that identifying a small number of fragment ions in a spectrum is sufficient for peptide identification. We consider y2-, y3-, b2-, and b3-ions and find the combination of b2-y2 to be sufficient for many peptides. Adding either the y3- or the b3-ion increases specificity and allows reliable peptide… CONTINUE READING

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