Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.

@article{Mierke2001PeptideHB,
  title={Peptide hormone binding to G-protein-coupled receptors: structural characterization via NMR techniques.},
  author={Dale F. Mierke and Craig Giragossian},
  journal={Medicinal research reviews},
  year={2001},
  volume={21 5},
  pages={450-71}
}
G-protein-coupled receptors (GPCRs) allow cells to respond to calcium, hormones, and neurotransmitters. Not surprisingly, they currently make up the largest family of validated drug targets. Rational drug design for molecular regulators targeting GPCRs has been limited to theoretical-based computational approaches. X-ray crystallography of intact GPCRs has provided the topological orientation of the seven transmembrane helices, but limited structural information of the extracellular and… CONTINUE READING

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