Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.

@article{IgnarTrowbridge1993PeptideGF,
  title={Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsive element.},
  author={D M Ignar-Trowbridge and Christina T. Teng and Kenneth A. Ross and Malcolm G. Parker and Kenneth S. Korach and J A McLachlan},
  journal={Molecular endocrinology},
  year={1993},
  volume={7 8},
  pages={992-8}
}
Epidermal growth factor (EGF) elicits estrogen receptor (ER)-dependent physiological sequelae and estrogen-like biochemical effects on the ER in the mouse uterus. These in vivo observations indicate that EGF may elicit some of its actions by activation of the ER. The effect of peptide growth factors on activation of a consensus estrogen-responsive element was assessed in a strain of Ishikawa human endometrial adenocarcinoma cells with negligible levels of ERs, as determined by Western blot and… CONTINUE READING
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