Peptide glyoxals: a novel class of inhibitor for serine and cysteine proteinases.

Abstract

A series of novel synthetic dipeptides, containing a C-terminal glyoxal grouping (-COCHO), have been tested as inhibitors against typical members of the serine- and cysteine-proteinase families. For example, the sequences benzyloxycarbonyl (Cbz)-Pro-Phe-CHO (I) and Cbz-Phe-Ala-CHO (II), which fulfil the known primary and secondary specificity requirements… (More)

1 Figure or Table

Topics

  • Presentations referencing similar topics