Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells

@inproceedings{Lee2015PeptideenhancedMT,
  title={Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells},
  author={Kunwoo Lee and Pengzhi Yu and Nithya Lingampalli and Hyun Jin Kim and Richard Tang and Niren Murthy},
  booktitle={International journal of nanomedicine},
  year={2015}
}
The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor mRNAs has the potential to regenerate cardiac tissue and to treat heart failure. Even though mRNA delivery to cardiac fibroblasts has the therapeutic potential, mRNA transfection in cardiac fibroblasts has been challenging. Herein, we develop an… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Induction of human cardiomyocyte-like cells from fibroblasts by defined factors.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2013
VIEW 1 EXCERPT

The cargo of CRPPR-conjugated liposomes crosses the intact murine cardiac endothelium.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2012
VIEW 1 EXCERPT

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