Peptide drugs accelerate BMP‐2‐induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling

Abstract

Both W9 and OP3-4 were known to bind the receptor activator of NF-κB ligand (RANKL), inhibiting osteoclastogenesis. Recently, both peptides were shown to stimulate osteoblast differentiation; however, the mechanism underlying the activity of these peptides remains to be clarified. A primary osteoblast culture showed that rapamycin, an mTORC1 inhibitor… (More)
DOI: 10.1002/bies.201600104

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Cite this paper

@inproceedings{Sugamori2016PeptideDA, title={Peptide drugs accelerate BMP‐2‐induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling}, author={Yasutaka Sugamori and Setsuko Mise‐Omata and Chizuko Maeda and Shigeki Aoki and Yasuhiko Tabata and Ramachandran Murali and Hisataka Yasuda and Nobuyuki Udagawa and Hiroshi Suzuki and Masashi Honma and Kazuhiro Aoki}, booktitle={BioEssays : news and reviews in molecular, cellular and developmental biology}, year={2016} }