Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance.

@article{Rogers1999PeptideDA,
  title={Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance.},
  author={Paul R. Rogers and Michael Croft},
  journal={Journal of immunology},
  year={1999},
  volume={163 3},
  pages={1205-13}
}
Opposing viewpoints exist regarding how Ag dose and affinity modulate Th1/Th2 differentiation, with data suggesting that both high and low level stimulation favors Th2 responses. With transgenic T cells bearing a single TCR, we present novel data, using peptides differing in affinity for the TCR, that show that the time period of differentiation can determine whether Th1 or Th2 responses predominate as the level of initial stimulation is altered. Over the short term, IFN-gamma-producing cells… CONTINUE READING

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