Peptide design and structural characterization of a GPCR loop mimetic.

  title={Peptide design and structural characterization of a GPCR loop mimetic.},
  author={T T Pham and Richard W. Kriwacki and Abby L. Parrill},
  volume={86 4},
G protein-coupled receptors (GPCRs) control fundamental aspects of human physiology and behaviors. Knowledge of their structures, especially for the loop regions, is limited and has principally been obtained from homology models, mutagenesis data, low resolution structural studies, and high resolution studies of peptide models of receptor segments. We developed an alternate methodology for structurally characterizing GPCR loops, using the human S1P(4) first extracellular loop (E1) as a model… CONTINUE READING


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