Peptide bond formation by in vitro selected ribozymes

@article{Zhang1997PeptideBF,
  title={Peptide bond formation by in vitro selected ribozymes},
  author={Biliang Zhang and Thomas R. Cech},
  journal={Nature},
  year={1997},
  volume={390},
  pages={96-100}
}
An attractive solution to the problem of the origin of protein synthesis in an evolving ‘RNA world’ involves catalysis by nucleic acid without assistance from proteins,. Indeed, even the modern ribosome has been considered to be fundamentally an RNA machine, and the large ribosomal subunit can carry out peptidyl transfer in the absence of most of its protein subunits. Successive cycles of in vitro selection and amplification have been used to find RNAs that perform many biochemical reactions… 

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The basic notions of transition state theory have been exploited in the past to generate highly selective catalysts from the vast library of antibody molecules in the immune system. These same ideas
...