Peptide-based delivery of steric-block PNA oligonucleotides.

Abstract

Several strategies based on synthetic oligonucleotides (ON) have been proposed to control gene expression. As for most biomolecules, however, delivery has remained a major roadblock for in vivo applications. Conjugation of steric-block neutral DNA mimics such as peptide nucleic acids (PNA) or phosphorodiamidate morpholino oligonucleotides (PMO) to cell… (More)
DOI: 10.1007/978-1-59745-429-2_6

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