Peptide aptamers with binding specificity for the intracellular domain of the ErbB2 receptor interfere with AKT signaling and sensitize breast cancer cells to Taxol.

Abstract

The ErbB2 receptor tyrosine kinase is overexpressed in approximately 30% of breast tumor cases and its overexpression correlates with an unfavorable prognosis. A major contributor for this course of the disease is the insensitivity of these tumors toward chemotherapy. Monoclonal antibodies, inhibiting the ligand-induced activation of the receptor and… (More)

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@article{Kunz2006PeptideAW, title={Peptide aptamers with binding specificity for the intracellular domain of the ErbB2 receptor interfere with AKT signaling and sensitize breast cancer cells to Taxol.}, author={Christian Kunz and Corina Borghouts and Claudia Buerger and Bernd Groner}, journal={Molecular cancer research : MCR}, year={2006}, volume={4 12}, pages={983-98} }