• Biology, Medicine
  • Published in
    The Journal of biological…
    1990

Peptide and protein carboxyl-terminal labeling through carboxypeptidase Y-catalyzed transpeptidation.

@article{Berne1990PeptideAP,
  title={Peptide and protein carboxyl-terminal labeling through carboxypeptidase Y-catalyzed transpeptidation.},
  author={P F Berne and Jean Marie. Schmitter and Sylvain Blanquet},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 32},
  pages={
          19551-9
        }
}
A survey of carboxypeptidase Y-catalyzed carboxyl-terminal modification of short peptides in the presence of various amino acids revealed that transpeptidation occurred in significant yield only with peptides containing a proline at the penultimate or antepenultimate position. For these peptides, transpeptidation was shown to occur specifically at the carboxyl side of the proline, thus suggesting a determining role of this residue for transpeptidation. Two model peptides, YPFP-GPI and YPFVEPI… CONTINUE READING

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