Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).

Abstract

The development of novel peptide and peptidomimetic ligands for the CXC chemokine receptor 4 (CXCR4) as therapeutic agents for HIV-1 infection, cancer, and immune system diseases has grown over the last decade. In this perspective article, the design of CXCR4 agonists and antagonists from endogenous stromal cell-derived factor-1 (SDF-1)/CXCL12 and horseshoe crab-derived antimicrobial peptides and their therapeutic and diagnostic applications are described.

DOI: 10.1039/c2ob25107h
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@article{Oishi2012PeptideAP, title={Peptide and peptidomimetic ligands for CXC chemokine receptor 4 (CXCR4).}, author={Shinya Oishi and Nobutaka Fujii}, journal={Organic & biomolecular chemistry}, year={2012}, volume={10 30}, pages={5720-31} }