Peptide amidating activity and gastrin processing in the developing sheep pancreas.

@article{Kapuscinski1995PeptideAA,
  title={Peptide amidating activity and gastrin processing in the developing sheep pancreas.},
  author={Miroslav Kapuscinski and Arthur Shulkes},
  journal={The Journal of endocrinology},
  year={1995},
  volume={145 1},
  pages={
          137-42
        }
}
Gastrin is a regulator of both gastric acidity and gastrointestinal growth and is expressed transiently in the neonatal ovine and human pancreas. C-terminal amidation of glycine extended gastrin (G-gly) to gastrin amide (G-amide) by peptidylglycine alpha-amidating mono-oxygenase (PAM) is the final processing step. To investigate the relationship between PAM and gastrin synthesis in the developing pancreas, we measured PAM activity and the concentrations of gastrins in ovine pancreatic extracts… CONTINUE READING