Peptide aldehydes as inhibitors of HIV protease.

  title={Peptide aldehydes as inhibitors of HIV protease.},
  author={Edoardo Sarubbi and Pierfausto Seneci and Michael R. Angelastro and Norton Paul Peet and M. T. Messina Denaro and Kh.Towkir-Ul Islam},
  journal={FEBS letters},
  volume={319 3},
We have recently shown that alpha-MAPI, a peptidic aldehyde of microbial origin, inhibits the HIV protease with a potency comparable to pepstatin, having, differently from pepstatin, no activity on other aspartic proteases. In this study different peptide derivatives containing a C-terminal aldehyde have been tested to assess the potential of this function for the inhibition of HIV protease. The results of our analysis correspond with the recently published subsite preferences of the viral… CONTINUE READING