Peptide YY in gastrointestinal disorders

  title={Peptide YY in gastrointestinal disorders},
  author={Magdy El-Salhy and Ole Bernt Suhr and {\AA}ke Danielsson},
The role of peptide YY in gastrointestinal diseases and disorders
Investigating changes in PYY in gastrointestinal diseases/disorders could be beneficial in clinical practice, where a receptor agonist or an antagonist can be used as a drug, depending on the condition.
Gastrointestinal neuroendocrine peptides/amines in inflammatory bowel disease
The GI NEPA are potentially useful for the diagnosis and follow-up of the activity of IBD, and are candidate targets for treatments of this disease.
Putative mechanisms of kiwifruit on maintenance of normal gastrointestinal function
An overview on the physiological and pathophysiological processes underlying constipation and IBS-C, the composition of kiwifruit, and recent advances in the research of k Kiwifruit and abdominal comfort is provided.
Changes in enteroendocrine and immune cells following colitis induction by TNBS in rats
Investigation of alterations in colonic endocrine cells in a rat model of IBD suggests the presence of interactions between intestinal hormones and immune cells.
Visceral hyperalgesia caused by peptide YY deletion and Y2 receptor antagonism
Ex vivo PYY has a hypoalgesic effect on somatic thermal and visceral chemical pain and seems to be mediated by peripheral Y2 receptors.
Classification and functions of enteroendocrine cells of the lower gastrointestinal tract
This review focuses on the EECs of the lower GI where new evidence also suggests a possible relationship with the development and progression of primary adenocarcinoma.
Peptide YY
Recent advances in the peptide YY field with regard to energy balance in both rodent and human models are highlighted, suggesting a possible combination therapy for reducing bodyweight.
Abnormalities in endocrine and immune cells are correlated in dextran-sulfate-sodium-induced colitis in rats
The densities of mucosal leukocytes, T and B lymphocytes, macrophages/monocytes, and mast cells were significantly higher than in the controls, and these changes were closely associated with the aforementioned changes in all endocrine cell types.


Gastrointestinal regulatory peptides in systemic sclerosis.
This study shows that elevated peptide concentrations commonly occur in patients with SSc, and further characterization of this neuroendocrine system may help in understanding the complex regulation of gastrointestinal dysfunction in SSc.
The nature and implication of intestinal endocrine cell changes in coeliac disease.
  • M. El-Salhy
  • Medicine, Biology
    Histology and histopathology
  • 1998
It is speculated further that the changes in the endocrine cells would cause an incomplete digestion of the ingested food and its rapid elimination from the intestine, which may be responsible for the diarrhoea and steatorrhoea that occur in patients with coeliac disease.
Colonic neuroendocrine peptide levels in patients with chronic idiopathic slow transit constipation.
It is concluded that patients with slow-transit constipation have disturbed neuroendocrine peptides in common, though the nature of this disturbance varies between patients and in most patients several neuroendocrin peptides were affected.
Disorders of gastrointestinal motility associated with diabetes mellitus.
Gastrointestinal symptoms such as vomiting, constipation, diarrhea, and fecal incontinence occur frequently in patients with diabetes mellitus and are thought to be due to abnormal gastrointestinal motility.
Increased plasma levels of peptide YY in coeliac disease.
The basal PYY levels were studied in four patients with newly diagnosed disease and had normalized within 8 months on a gluten-free diet, and were inversely correlated to the concentration of folate acid in serum.
Bile acid malabsorption caused by gastrointestinal motility dysfunction? An investigation of gastrointestinal disturbances in familial amyloidosis with polyneuropathy.
Bile acid malabsorption is frequently encountered in familial amyloidsosis with polyneuropathy and seems to be more closely associated with gastrointestinal motility dysfunction than with amyloid deposits in the intestinal mucosa.
Diabetic Gastropathy (Gastric Neuromuscular Dysfunction in Diabetes Mellitus A Review of Symptoms, Pathophysiology, and Treatment)
  • K. Koch
  • Medicine
    Digestive Diseases and Sciences
  • 2004
Diabetic gastropathy is a term that encompassesa number of neuromuscular dysfunctions of the stomach,including abnormalities of gastric contractility, tone,and myoelectrical activity in patients with
Abnormal colonic endocrine cells in patients with chronic idiopathic slow-transit constipation.
The changes in colonic endocrine cells in patients with slow-transit constipation may be one cause of the decreased motility in the colon and consequent development of constipation.
Neuropeptides in idiopathic chronic constipation (slow transit constipation)
  • K. Sjölund, S. Fasth, F. Sundler
  • Biology
    Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
  • 1997
Tissue specimens from the large bowel of 18 patients with long‐standing slow transit constipation were investigated to determine the distribution and density of several neuropeptides and amines in