Peptide YY as a growth factor for intestinal epithelium

  title={Peptide YY as a growth factor for intestinal epithelium},
  author={Peter J. Mannon},
  • P. Mannon
  • Published 1 February 2002
  • Biology, Medicine
  • Peptides
Peptide YY: A neuroendocrine neighbor of note
Peptide Yy Peptide Yy and Analogs Offered by Bachem
A role in " long-term " regulation of food intake was suggested for PYY (3-36), a gut hormone which was first isolated in 1980 by Takemoto and coworkers from porcine intestine and plays an important role in regulating gastrointestinal secretion and motility.
PYY in the expanding pancreatic epithelium
The data suggest that PYY may be a mediator of islet cell development, as well as a cofactor for growth factor responses, not only during fetal pancreas formation but also during regeneration in adult animals.
Peptide YY: more than just an appetite regulator
Evidence supporting the concept that PYY and NPY receptors are exciting new targets for the preservation of beta cells is focused on.
Emerging therapeutic potential for peptide YY for obesity-diabetes


Stimulatory Actions of Insulin-Like Growth Factor-I and Transforming Growth Factor-α on Intestinal Neurotensin and Peptide YY1.
The purpose of these studies was to examine the effects of IGF-I and TGF-α on stomach gastrin and intestinal NT and PYY gene expression and secretion and the stimulatory actions of these growth factors or gastrointestinal hormones on the gastrointestinal mucosa.
Is raised plasma peptide YY after intestinal resection in the rat responsible for the trophic response?
Plasma PYY correlates both with crypt cell production rate in the ileum and with plasma enteroglucagon levels, and it is unlikely that PYY exerts a major trophic effect on the gastrointestinal tract.
Is peptide YY trophic to the intestinal epithelium of parenterally fed rats?
It is concluded that PYY is not trophic to the gastrointestinal tract and no significant effect on intestinal tissue mass or the 2-hour collection of metaphases was observed.
Distribution of common peptide YY-neuropeptide Y receptor along rat intestinal villus-crypt axis.
Rat small intestinal epithelium is equipped with peptide YY (PYY)-preferring receptors, which also recognize neuropeptide Y (NPY) with high affinity, which indicate that PYY-preferredring receptors are preferentially expressed in crypt cells where intestinal ionic secretion is believed to take place.
Intestinal peptide YY: ontogeny of gene expression in rat bowel and trophic actions on rat and mouse bowel.
The trophic effects of PYY were dose related, peptide specific, and independent of species and sex, hypothesize that PYY plays an important role in intestinal development and dietary adaptation in rats and mice.
Peptide YY Y1 receptor activates mitogen-activated protein kinase and proliferation in gut epithelial cells via the epidermal growth factor receptor.
A novel pathway involving G(i)/G(o) protein, EGFR and PKC to activate MAPK is demonstrated and it is shown that PYY stimulates growth in Y1R-expressing gut epithelial cells that is dependent on EGFR TK activity.
Signaling mechanisms of glucagon-like peptide 2-induced intestinal epithelial cell proliferation.
An increase in Caco-2 proliferation in response to GLP-2 may be due, at least in part, to the involvement of both the PI 3-kinase and the MAPK pathways.
Effects of keratinocyte growth factor (KGF) on gut growth and repair
The idea that KGF is involved in the control of proliferation of the gastrointestinal tract is supported, however, for a role in the early reparative process invoked during short‐term models of gastrointestinal injury is not provided.