Peptide YY Secretion in Morbidly Obese Patients Before and After Vertical Banded Gastroplasty

@article{Bartolom2002PeptideYS,
  title={Peptide YY Secretion in Morbidly Obese Patients Before and After Vertical Banded Gastroplasty},
  author={Mercedes Alvarez Bartolom{\'e} and Mar{\'i}a Jes{\'u}s Borque and Javier Mart{\'i}nez-Sarmiento and Eugenio Aparicio and Carmen Hern{\'a}ndez and Lucio Cabrerizo and Jes{\'u}s Alvarez Fern{\'a}ndez-Represa},
  journal={Obesity Surgery},
  year={2002},
  volume={12},
  pages={324-327}
}
Background: The Peptide YY (PYY) secretion pattern was assessed in morbidly obese (MO) patients before and after vertical banded gastroplasty (VBG). Methods: 12 MO patients (10 women, 2 men) age 29-62 years, BMI 50.7 ± 9.6 kg/m2, treated with a VBG were studied. Before surgery, blood samples were taken in basal conditions of fasting and 10, 15, 20, 30 and 60 min after the ingestion of a semiliquid test meal. This was repeated in the same patients 6 and 12 months after VBG. Blood samples were… 
Alterations in Gut Hormones After Laparoscopic Sleeve Gastrectomy: A Prospective Clinical and Laboratory Investigational Study
TLDR
LSG markedly improved glucose homeostasis and generated significant changes in ghrelin, PP, PYY, GLP-1, amylin, and leptin levels, demonstrating that LSG could be more than just a restrictive bariatric operation.
Ghrelin and Peptide YY Levels after a Variant of Biliopancreatic Diversion with Roux-en-Y Gastric Bypass versus after Colectomy: A Prospective Comparative Study
TLDR
The great postoperative increase in the levels of the anorexigenic peptide PYY following BPD-RYGBP may contribute to the reduced appetite observed after this type of bariatric surgery.
Effect of Weight Loss by Diet or Gastric Bypass Surgery on Peptide YY3–36 Levels
TLDR
GBP, but not diet-induced weight loss, resulted in markedly increased glucose-stimulated PYY3–36 levels, which is likely a result of the surgery rather than a secondary outcome of weight loss.
The cholestyramine-induced decrease of PYY postprandial response is negatively correlated with fat mass in obese women.
  • A. Rigamonti, M. Resnik, A. Sartorio
  • Medicine, Biology
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2011
TLDR
This study implies that in the obese state the altered PYY response to food consumption is a consequence of a dysfunction of L cells, which become less sensitive to the positive feedback effect of lipids.
Effects of vagus nerve preservation and vagotomy on peptide YY and body weight after subtotal gastrectomy.
TLDR
Vagus nerve preservation contributes to the maintenance of body weight after gastrectomy, and this phenomenon may be related to the suppressed activity of peptide YY(3-36).
Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss.
TLDR
PYY is negatively correlated to the degree of overweight, with reduced values in obese compared with normal-weight children, and low pretreatment PYY levels that increase during weight loss may be a predictor of maintained weight loss.
Peptide YY and Glucagon-like Peptide-1 in Morbidly Obese Patients Before and After Surgically Induced Weight Loss
TLDR
In morbidly obese adults reducing their weight by bariatric surgery, fasting PYY levels increased and GLP-1 concentrations decreased independently of each other, which seems more complicated than might be anticipated from animal and in vitro studies.
Medical and surgical treatments for obesity have opposite effects on peptide YY and appetite: a prospective study controlled for weight loss.
TLDR
RYGB and SG increased PYY and reduced appetite before and after Roux-en-Y gastric bypass, sleeve gastrectomy, and medical treatment suggests that the weight-loss effects of these procedures are enhanced by an increase in PYYand satiety.
Short-term regulation of peptide YY secretion by a mixed meal or peritoneal glucose-based dialysate in patients with chronic renal failure.
  • M. Pérez-Fontán, F. Cordido, J. García-Buela
  • Medicine, Biology
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2008
TLDR
Baseline plasma levels of peptide YY or PYY(3-36) are markedly elevated in patients with renal failure undergoing peritoneal dialysis, and this findings may contribute to clarify the complex pathogenesis of anorexia of chronic renal failure.
Effect of somatostatin infusion on peptide YY secretion: studies in the acute and recovery phase of anorexia nervosa and in obesity.
TLDR
The results suggest the existence of a hypo- and hyper-sensitivity of L cells to the inhibitory effect of SRIF in A-AN and OB respectively.
...
...

References

SHOWING 1-10 OF 17 REFERENCES
Release of peptide YY (PYY) after resection of small bowel, colon, or pancreas in man.
TLDR
PYY does not appear to have a role in the adaptive trophic response after small intestinal resection, but it may contribute to reduction of gastric secretion and gastrointestinal transit in patients with resected small or large intestines.
Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity
TLDR
Both fasting and postprandial gut hormone levels are elevated 20 y after jejunoileal bypass, and the impact of long-term rapid stimulation of the ileum and subsequent raised Gut hormone levels on gastric emptying is not clear.
Distal Small Bowel Hormones (Correlation with Fasting Antroduodenal Motility and Gastric Emptying)
The aim of the present study was to study theinterdigestive motor complex (MMC), distal smallintestinal hormones, and gastric emptying innormal-weight and obese subjects before and afterjejunoileal
Gastroplasty as a treatment for massive obesity. A clinical and biochemical evaluation.
Twenty-four grossly obese patients were operated on with horizontal gastroplasty. One patient died postoperatively of pulmonary embolism. The remaining 23 were extensively studied before and
Gastric and oesophageal emptying in obesity.
TLDR
It is indicated that delayed gastric and oesophageal emptying occurs frequently in obesity and that these abnormalities relate to body weight.
Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers.
TLDR
The infusion of PYY shows a dose related inhibition of mouth to caecum intestinal transit time and of the rate of gastric emptying and suggests this novel hormonal peptide to be of importance in gastrointestinal physiology.
Gastrointestinal hormones in short bowel syndrome. Peptide YY may be the 'colonic brake' to gastric emptying.
TLDR
Low peptide YY values in short bowel patients without a colon may cause rapid gastric emptying of liquid and contribute to the "colonic brake".
Cholecystokinin Mediation of Colonic Absorption Via Peptide YY: Foregut–Hindgut Axis
TLDR
Reduction of meal-induced colonic absorption and PYY release by MK329 in awake dogs suggests an important foregut–hindgut hormonal feedback loop, which in turn stimulates Colonic absorption while inhibiting further CCK release.
...
...