Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses

@inproceedings{Cox2010PeptideYI,
  title={Peptide YY Is Critical for Acylethanolamine Receptor Gpr119-Induced Activation of Gastrointestinal Mucosal Responses},
  author={Helen M Cox and Iain R Tough and Anne-Marie Woolston and Lei Zhang and Amy D. Nguyen and Amanda Sainsbury and Herbert Herzog},
  booktitle={Cell metabolism},
  year={2010}
}
Peptide YY (PYY) is released following food intake and regulates intestinal function and glucose homeostasis, but the mechanisms underpinning these processes are unclear. Enteroendocrine L cells contain PYY and express the acylethanolamine receptor, Gpr119. Here, we show that Gpr119 activation inhibited epithelial electrolyte secretion in human and mouse colon in a glucose-sensitive manner. Endogenous PYY selectively mediated these effects, since PYY(-/-) mice showed no Gpr119 response, but… CONTINUE READING

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