PYY3-36 inhibits the action potential firing activity of POMC neurons of arcuate nucleus through postsynaptic Y2 receptors.
- BiologyCell metabolism
Characterization of brainstem peptide YY (PYY) neurons
- BiologyThe Journal of comparative neurology
The projection pattern and association with orexigenic neuropeptides suggest that brainstem PYY neurons may play a role in energy homeostasis through a coordinated effect on visceral, motor, and sympathetic output targets.
Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide.
- BiologyAmerican journal of physiology. Gastrointestinal and liver physiology
This review considers the anorectic peptides PYY, PP, GLP-1, and oxyntomodulin, which decrease appetite and promote satiety in both animal models and humans.
Peptide YY signaling in the lateral parabrachial nucleus increases food intake through the Y1 receptor.
- BiologyAmerican journal of physiology. Endocrinology and metabolism
The present studies investigate the contribution of lateral parabrachial nucleus (lPBN) PYY-Y receptor signaling to food intake control, as lPBN neurons express Y receptors and receive PYY fibers and are known to integrate circulating and visceral sensory signals to regulate energy balance.
Peptide YY3-36 inhibits food intake in mice through a melanocortin-4 receptor-independent mechanism.
It is demonstrated that, like cholecystokinin, PYY(3-36) dose-dependently inhibits food intake by approximately 20-45% over a 3- to 4-h period post ip administration, with no effect on 12-h food intake, and PYY-induced satiety is atypical, because it does not produce detectable activation of brainstem satiety centers and is not dependent on MC4-R signaling.
PYY3‐36 as an anti‐obesity drug target
- BiologyObesity reviews : an official journal of the International Association for the Study of Obesity
Data speak against a sustained decrease in food intake, body fat, or body weight gain following PYY3‐36 administration and make the previously suggested role of the hypothalamic melanocortin system unlikely as is the existence of PYY deficiency in human obesity.
Neuropeptides, food intake and body weight regulation: a hypothalamic focus
- Biology, PsychologyPeptides
NPY Effects on Food Intake and Metabolism
- Biology, Psychology
Based on the available evidence, it is concluded that NPY probably plays a role in the day-to- day control of food intake and is not a critical regulator ofFood intake.
SHOWING 1-10 OF 61 REFERENCES
Suppression of peptide YY-induced hyperphagia by terbutaline
- BiologyPharmacology Biochemistry and Behavior
Cerebrospinal fluid peptide YY immunoreactivity in eating disorders.
- Psychology, BiologyNeuropsychobiology
Results suggest that bulimic behavior may correct a central nervous system abnormality in PYY, a recently discovered peptide that is a potent stimulant of eating behavior in rats.
Role of hypothalamic neuropeptide Y in feeding and obesity
Development of specific receptor antagonists with improved pharmacokinetic properties will be required to determine the importance of NPY in human obesity and appetite disorders.
The discriminative stimulus effects of neuropeptide Y
- Biology, PsychologyBrain Research
Effect of peptide YY (PYY) on food-associated conflict
- Psychology, BiologyPhysiology & Behavior
Effect of naloxone and antidepressants on hyperphagia produced by peptide YY
- Biology, PsychologyPharmacology Biochemistry and Behavior
Paraventricular nucleus injections of peptide YY and neuropeptide Y preferentially enhance carbohydrate ingestion
The effect of hypothalamic peptide YY on hippocampal acetylcholine release in vivo: implications for limbic function in binge-eating behavior
- Biology, PsychologyBrain Research
Effect of fourth ventricular neuropeptide Y and peptide YY on ingestive and other behaviors.
- Biology, PsychologyThe American journal of physiology
PYY was more potent than NPY in increasing food intake and decreasing latency to eat, suggesting that PYY-preferring receptors sensitive to the orexigenic effects of NPY and PYY exist in the hindbrain.