Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats.

@article{Beck2005PeptideSI,
  title={Peptide S is a novel potent inhibitor of voluntary and fast-induced food intake in rats.},
  author={Bernard Beck and Brigitte Fernette and Alain Stricker-Krongrad},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={332 3},
  pages={859-65}
}
Peptide S (NPS or PEPS) and its cognate receptor have been recently identified both in the central nervous system and in the periphery. NPS/PEPS promotes arousal and has potent anxiolytic-like effects when it is injected centrally in mice. In the present experiment, we tested by different approaches its central effects on feeding behaviour in Long-Evans rats. PEPS at doses of 1 and 10 microg injected in the lateral brain ventricle strongly inhibited by more than 50% chow intake in overnight… CONTINUE READING
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