Peptide Reactivity of Isothiocyanates – Implications for Skin Allergy

  title={Peptide Reactivity of Isothiocyanates – Implications for Skin Allergy},
  author={Isabella Karlsson and Kristin Samuelsson and David Ponting and Margareta T{\"o}rnqvist and Leopold L Ilag and Ulrika Nilsson},
  booktitle={Scientific reports},
Skin allergy is a chronic condition that affects about 20% of the population of the western world. This disease is caused by small reactive compounds, haptens, able to penetrate into the epidermis and modify endogenous proteins, thereby triggering an immunogenic reaction. Phenyl isothiocyanate (PITC) and ethyl isothiocyanate (EITC) have been suggested to be responsible for allergic skin reactions to chloroprene rubber, the main constituent of wetsuits, orthopedic braces, and many types of… CONTINUE READING