Peptide Paratope Mimics of the Broadly Neutralizing HIV-1 Antibody b12.

Abstract

The broadly neutralizing HIV-1 antibody b12 recognizes the CD4 binding site of the HIV-1 envelope glycoprotein gp120 and efficiently neutralizes HIV-1 infections in vitro and in vivo. Based on the 3D structure of a b12⋅gp120 complex, we have designed an assembled peptide (b12-M) that presents the parts of the three heavy-chain complementarity-determining… (More)
DOI: 10.1002/cbic.201600621

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