Peptide-Based Delivery of Oligonucleotides Across Blood–Brain Barrier Model

Abstract

Delivery of pharmaceutical agents across a blood–brain barrier (BBB) is a challenge for brain cancer therapy. In this study, an in vitro BBB model was utilized to study the delivery of oligonucleotides across brain endothelial cells targeting to glioma cells in a Transwell™ setup. A series of novel peptides were synthesized by covalent conjugation of cell… (More)
DOI: 10.1007/s10989-013-9378-4

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Cite this paper

@article{Srimanee2013PeptideBasedDO, title={Peptide-Based Delivery of Oligonucleotides Across Blood–Brain Barrier Model}, author={Artita Srimanee and Jakob Regberg and Mattias Hallbrink and Kaido Kurrikoff and Kadi-Liis Veiman and Opa Vajragupta and {\"U}lo Langel}, journal={International Journal of Peptide Research and Therapeutics}, year={2013}, volume={20}, pages={169-178} }