Peptidases trimming MHC class I ligands.

  title={Peptidases trimming MHC class I ligands.},
  author={Mirjana Weimershaus and Irini Evnouchidou and Loredana Saveanu and Peter van Endert},
  journal={Current opinion in immunology},
  volume={25 1},
Peptides presented by MHC class I molecules are typically produced through antigen degradation by the proteasome followed by trimming by exopeptidases. According to recent results, these include both aminopeptidases and carboxypeptidases in the cytosol and the endoplasmic reticulum. While cytosolic peptidases have a net neutral or destructive effect on MHC ligands, endoplasmic reticulum aminopeptidases are required for efficient class I loading and have a strong effect on the repertoire of… CONTINUE READING
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