Peptidase activity as a determinant of agonist potencies in some smooth muscle preparations.

@article{Hall1990PeptidaseAA,
  title={Peptidase activity as a determinant of agonist potencies in some smooth muscle preparations.},
  author={James A M Hall and Alyson J. Fox and Ian K. M. Morton},
  journal={European journal of pharmacology},
  year={1990},
  volume={176 2},
  pages={127-34}
}
The influence of degradation by peptidases on concentration-response relationships for peptide agonists of the tachykinin and bombesin-like families was investigated. The combined presence of three peptidase inhibitors, phosphoramidon (1 microM), captopril (1 microM) and bestatin (100 microM), had no significant effect on the onset rates or peak contractile responses to these peptides in the rat urinary bladder and guinea-pig taenia caeci preparations, or on their peak potentiation of the… CONTINUE READING