The authors studied the clinical aspects, indices of gastric secretion and basal level blood serum insulin, gastrin and parathormone in 83 patients with ulcer disease recurrence after vagotomy. All patients showed an active acidopeptic factor--sequel of ineffective and incomplete (in some patients) vagotomy as well as inadequate pyloroplasty. Provoking factors of ulcer disease recurrence may be stress, drugs, duodenogastric reflux, presence of ligatures after pyloroplasty. Surgical treatment is indicated in patients with surgical complications, repeatedly relapsing ulcers. Recurrences with moderate course are successfully treated by traditional means and the patients retain working capacity due to seasonal or all-year prophylaxis.