Pepstatin inhibition of human renin. Kinetic studies and estimation of enzyme purity.

Abstract

Pepstatin has been shown to be an extremely potent inhibitor of human renin (Ki = 1.3 X lo-lo M). Kinetic analyses by several techniques show reversible interaction of pepstatin with renin and classical noncofipetitive inhibition. The high affinity of pepstatin for renin allows kinetic determination of the molarity of the enzyme in partially purified… (More)

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@article{McKown1974PepstatinIO, title={Pepstatin inhibition of human renin. Kinetic studies and estimation of enzyme purity.}, author={M M McKown and Ronald Workman and Robert I. Gregerman}, journal={The Journal of biological chemistry}, year={1974}, volume={249 24}, pages={7770-4} }