Pepsin and Carbonic Anhydrase Isoenzyme III as Diagnostic Markers for Laryngopharyngeal Reflux Disease

@article{Johnston2004PepsinAC,
  title={Pepsin and Carbonic Anhydrase Isoenzyme III as Diagnostic Markers for Laryngopharyngeal Reflux Disease},
  author={Nikki Johnston and John Knight and Peter William Dettmar and Mark O. Lively and James A. Koufman},
  journal={The Laryngoscope},
  year={2004},
  volume={114}
}
Objectives/Hypothesis: The objective was to investigate the potential use of pepsin and carbonic anhydrase isoenzyme III (CA‐III) as diagnostic markers for laryngopharyngeal reflux disease. 
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Objectives:  To compare pepsin, carbonic anhydrase III (CAIII), cyclooxygenase‐2 (COX‐2) and mucin 5AC (MUC5AC) expression in children with adenoid hypertrophy and normal controls.
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TLDR
To assess if, as previously reported in the literature, bile acids inhibit pepin activity, resulting in pepsin having a less important role in laryngopharyngeal damage in reflux disease, biliary acid inhibition is reported to have a role in this disease.
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Whether pepsin has to be enzymatically active to deplete laryngeal protective proteins, carbonic anhydrase isoenzyme III (CAIII), and squamous epithelial stress protein Sep70 is determined.
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TLDR
If there is a higher reflux burden as measured by pH‐MII in patients that are pepsin positive in the lung, and the sensitivity of pepsin in predicting pathologic reflux by pH, MII, and EGD is studied.
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To investigate whether the pepsin immunohistochemical (IHC) staining of the laryngeal mucosa epithelia is an available test for diagnosing laryngopharyngeal reflux (LPR) in clinic.
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Abstract Reflux of gastric contents into the laryngopharynx contributes to voice disorders, otolaryngological inflammatory disorders, and perhaps even neoplastic diseases of the laryngopharynx. Tre...
Saliva Pepsin Concentration of Laryngopharyngeal Reflux Patients Is Influenced by Meals Consumed Before the Samples
TLDR
The objective was to assess the impact of diet on the saliva pepsin concentration of patients with laryngopharyngeal reflux and to establish a smoking cessation strategy for patients with LPR.
The Role of Pepsin in Laryngopharyngeal Reflux
TLDR
This review focuses on the current studies about pepsin as a specific marker for LPR and putative relationship between pepingin and laryngeal cancer.
Optimal timing of saliva collection to detect pepsin in patients with laryngopharyngeal reflux
TLDR
To determine salivary pepsin levels as a function of collection time, a single sample of saliva from eight adults was collected over a 12-week period to establish a baseline level.
Pepsin as a Marker of Extraesophageal Reflux
TLDR
Pepsin assay is a useful tool for correlation of reflux with airway disease and is a reliable diagnostic marker of EER.
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