Peppermint Oil for the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

@article{Khanna2014PeppermintOF,
  title={Peppermint Oil for the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis},
  author={Reena Khanna and John K Macdonald and Barrett G. Levesque},
  journal={Journal of Clinical Gastroenterology},
  year={2014},
  volume={48},
  pages={505–512}
}
Goals: The aim of this study was to assess the efficacy and safety of enteric-coated peppermint oil capsules compared with placebo for the treatment of active irritable bowel syndrome (IBS). Background: IBS is a common disorder that is often encountered in clinical practice. Medical interventions are limited and the focus is on symptom control. Study: Randomized placebo-controlled trials with a minimum treatment duration of 2 weeks were considered for inclusion. Cross-over studies that provided… 

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References

SHOWING 1-10 OF 45 REFERENCES

Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis

TLDR
The role of peppermint oil in the symptomatic treatment of IBS has so far not been established beyond reasonable doubt, and a metaanalysis of five placebo-controlled, double blind trials seems to support this notion.

Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis

TLDR
Fibre, antispasmodics, and peppermint oil were all more effective than placebo in the treatment of irritable bowel syndrome.

Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial.

Efficacy of Peppermint oil in diarrhea predominant IBS - a double blind randomized placebo - controlled study.

TLDR
The study result concludes that peppermint oil is effective in reliving only abdominal pain in diarrhea predominant IBS transiently.

PEPPERMINT OIL AND IRRITABLE BOWEL SYNDROME

  • T. R. Koch
  • Medicine
    American Journal of Gastroenterology
  • 1998
TLDR
It is concluded that Colpermin was effective and well tolerated and there were no significant changes in liver function test results.

Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children.

TLDR
Peppermint oil may be used as a therapeutic agent during the symptomatic phase of IBS and reduced severity of pain associated with IBS.

Stress management for irritable bowel syndrome: a controlled trial.

TLDR
Two thirds of those in the stress management programme found the programme effective in relieving symptoms and experienced fewer attacks of less severity and this benefit was maintained for at least 12 months.

Gastrointestinal clinical pharmacology of peppermint oil.

Functional bowel disorders and functional abdominal pain

TLDR
A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.