Peppermint Oil for the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis

  title={Peppermint Oil for the Treatment of Irritable Bowel Syndrome: A Systematic Review and Meta-analysis},
  author={Reena Khanna and John K Macdonald and Barrett G. Levesque},
  journal={Journal of Clinical Gastroenterology},
Goals: The aim of this study was to assess the efficacy and safety of enteric-coated peppermint oil capsules compared with placebo for the treatment of active irritable bowel syndrome (IBS). Background: IBS is a common disorder that is often encountered in clinical practice. Medical interventions are limited and the focus is on symptom control. Study: Randomized placebo-controlled trials with a minimum treatment duration of 2 weeks were considered for inclusion. Cross-over studies that provided… 

The impact of peppermint oil on the irritable bowel syndrome: a meta-analysis of the pooled clinical data

In the most comprehensive meta-analysis to date, peppermint oil was shown to be a safe and effective therapy for pain and global symptoms in adults with IBS.

Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial

Peppermint oil and placebo both showed clinically meaningful improvement in IBS symptoms, however, there were no significant differences between the groups.

Efficacy and Safety of Peppermint Oil in a Randomized Double-blind Trial of Patients With Irritable Bowel Syndrome.

In a randomized trial of patients with IBS, it was found that neither small-intestinal-release nor ileocolonic-release peppermint oil produced statistically significant reductions in abdominal pain response or overall symptom relief, when using FDA/EMA recommended endpoints.

Efficacy of probiotic adjuvant therapy for irritable bowel syndrome in children: A systematic review and meta-analysis

Objective Irritable bowel syndrome (IBS) affects children’s quality of life and learning. The purpose of this research was to systematically evaluate the efficacy of probiotic adjuvant therapy for

A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms

A novel PO formulation designed for sustained release in the small intestine is a safe, effective treatment capable of providing rapid relief of IBS symptoms.

Small intestine-release peppermint oil is beneficial in the treatment of irritable bowel syndrome

Evidence from systematic reviews has suggested that peppermint oil is an effective agent for the management of irritable bowel syndrome; however, results of a recent trial show that the type of

Effectiveness of Menthacarin on symptoms of irritable bowel syndrome

The reduction of IBS-associated symptoms in FD patients suggests Menthacarin as a treatment option for IBS patients, and the subgroup analysis indicates beneficial treatment effects of MenthACarin that are similar to those found for FD patients in the primary analyses.

Effect of Peppermint Oil on Premenstrual Syndrome: A Randomized, Double-Blind Placebo-Controlled Study

The proposed novel peppermint oil formulation was proved to be safe and may be used as an effective treatment for reducing the severity of PMS symptoms.

Does peppermint oil reduce symptoms in irritable bowel syndrome?

Compared with placebo, peppermint oil is a safe and effective short-term therapy for improvement of irritable bowel syndrome symptoms, including abdominal pain. Adverse events are mild and transient,



Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis

The role of peppermint oil in the symptomatic treatment of IBS has so far not been established beyond reasonable doubt, and a metaanalysis of five placebo-controlled, double blind trials seems to support this notion.

Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis

Fibre, antispasmodics, and peppermint oil were all more effective than placebo in the treatment of irritable bowel syndrome.

Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial.

Efficacy of Peppermint oil in diarrhea predominant IBS - a double blind randomized placebo - controlled study.

The study result concludes that peppermint oil is effective in reliving only abdominal pain in diarrhea predominant IBS transiently.


  • T. R. Koch
  • Medicine
    American Journal of Gastroenterology
  • 1998
It is concluded that Colpermin was effective and well tolerated and there were no significant changes in liver function test results.

Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children.

Peppermint oil may be used as a therapeutic agent during the symptomatic phase of IBS and reduced severity of pain associated with IBS.

Stress management for irritable bowel syndrome: a controlled trial.

Two thirds of those in the stress management programme found the programme effective in relieving symptoms and experienced fewer attacks of less severity and this benefit was maintained for at least 12 months.

Gastrointestinal clinical pharmacology of peppermint oil.

Functional bowel disorders and functional abdominal pain

A committee consensus approach, including criticism from multinational expert reviewers, was used to revise the diagnostic criteria and update diagnosis and treatment recommendations, based on research results.